Medion Diagnostics AG CH-3186 Düdingen

Product list		ABO Blood Grouping Mono-Type® Our monoclonal ABO antisera are produced using in-vitro cell culture of mouse hybridoma cell lines. This ensures constant specificity and the reagents are free of unwanted anti-T. Due to the non-human origin, there is no risk of infection for HIV or Hepatitis. For Anti-A Mono-Type® two and for Anti-B Mono-Type®, one clone is used. Anti-A,B-Mono-Type® is composed of 3 monoclonal antibodies where, however, not just anti-A and anti-B antibodies are blended but where true anti-AB antibodies are blended in order to assure optimal reactivity. The reaction strengths of our monoclonal ABO antisera are adjusted in a way that they equal human antisera while still recognizing weak A variants. Our Anti-A,B Mono-Type®, antisera reacted in field trials significantly better than the polyclonal antisera used earlier. Characteristics Facilitate the correct ABO determination through good reactivity even with a weak antigen expression (especially advantageous with samples from newborns or patients having leukemia) Reactivity is adjusted to ensure a clear recognition of weak subgroups Ensure through their monoclonal origin correct results with polyagglutinateable red cells Allow for a rapid emergency diagnosis while fulfilling all requirements of the routine lab Free of infectious pathogens of human origin 2 years shelf life Results from external evaluation 8 institutes in Europe and in the US reported with more than 5’000 patient samples correct and reliable results. The very few discrepancies between the polyclonal and our monoclonal antisera could be related to rouleaux formation or very weak antigen expression. However, in all cases the results obtained by using our Mono-Type® test sera were correct. 247 cord bloods were typed correctly. Samples, which gave a weak reaction with polyclonal antisera showed a reaction, which was one two steps stronger when using Mono-Type®. Anti-A,B Mono-Type® reacted with weak A and B subgroups significantly better compared to the polyclonal antiserum when tested in parallel. Lectins For the determination of the A subgroups Lectin-A1 is available, which is extracted out of Dolichos biflorus. Anti-H Lectin, which is prepared out of Ulex europaeus, is used for the detection of secretor characteristics in saliva and can be used for the determination of the H antigen on the red cell surface. Product listtop